Bill Hong

Bill Hong








I graduated at POSTECH in South Korea. During the Ph D. course I developed the novel organic coating layers for biosensor/chip and commercialized them. Now I’m working for developing nanobiomaterials for drug delivery and biosensors.


  • Ph.D., POSTECH, South Korea B.S. 

  • M.S. in Chemistry POSTECH, South Korea
  • B.S. in Chemistry, POSTECH, South Korea

Research focus: 

My research is focused on the synthesis of small molecule-DNA hybrids (SMDHs) and their assembly, as well as the development of novel organic nanoparticles for biological and medical applications. Using a variety of analytical methods of characterization, including matrix-assisted laser desorption ionization, optical absorption/emission spectroscopies, transmission electron microscopy, atomic force microscopy, and gel electrophoresis, together with theoretical calculations, I examine the assembly behaviors of the hybrid molecules and figure out parameters to make an effect on their assembly.  These results can serve as an enabling guideline for researchers to design and develop DNA-hybrid materials for a wide range of applications.


B. J. Hong, O. C. Compton, Z. An, and S. T. Nguyen, “Tunable Biomolecular Interaction and Fluorescence Quenching Ability of Graphene Oxide: Application to “Turn-on” DNA Sensing in Biological Media.”, Small submitted (2012).

B. J. Hong, O. C. Compton, Z. An, I. Eryzazici, and S. T. Nguyen, “Successful Stabilization of Graphene Oxide in Electrolyte Solutions: Enhancement of Bio-functionalization and Cellular Uptake.”, ACS Nano ASAP 10.1021/nn202355p (2011).

O. C. Compton, Z. An, K. W. Putz, B. J. Hong, B. G. Hauser, L. C. Brinson, and S. T. Nguyen, “Additive-free hydrogelation of graphene oxide by ultrasonication”, Carbons submitted (2011)

C. Y. Lee, O. K. Farha, B. J. Hong, A. A. Sarjeant, S. T. Nguyen, and J. T. Hupp, “Light-Harvesting Metal–Organic Frameworks (MOFs): Efficient Strut-to-Strut Energy Transfer in Bodipy and Porphyrin-Based MOFs”, J. Am. Chem. Soc. 133(40), 15858-15861 (2011).

E. S. Kim, B. J. Hong, C. W. Park, Y. Kim, J. W. Park, and K. Y. Choi, “Effects of Lateral Spacing on Enzymatic On-chip DNA Polymerization”, Biosens. Bioelectron. 26, 2566-2573 (2011).

S-. M. Lee, Y. Song, B. J. Hong, K. W. MacRenaris, D. J. Mastarone, T. V. O’Halloran, T. J. Meade, and S. T. Nguyen, “Modular Polymer-Caged Nanobins as a Theranostic Platform with Enhanced Magnetic Resonance Relaxivity and pH-Responsive Drug Release”, Angew. Chem., Int. Ed. 49, 9960-9964 (2010).

B. H. Hong, S. J. Oh, B. J. Hong, D. S. Jang, Y. S. Yun, J. W. Park, and K. Y. Choi, “Oligonucleotide Mcroarrays with High Discriminating Power for the Detection of Single Nucleotide Variations in the p53 Gene”, Mol. Cells 30(6), 575-579 (2010).

S. J. Oh, B. J. Hong, V. Sunkara, E. Ko, K. Y. Choi, and J. W. Park, “Biochips Nanotechnology: Chapter 10. DNA Microarrays on Nanoscale-Controlled Mesospaced Surface with Enhanced Selectivity and Sensitivity”, American Scientific Publishers, 317-343 (2009).

Y. J. Jung, B. J. Hong, , W. Zhang, S. J. B. Tendler, P. M. Williams, S. Allen, and J. W. Park, “Dendron Arrays for the Force-Based Detection of DNA Hybridization Events”, J. Am. Chem. Soc. 129, 9349-9355 (2007).

S. H. Kwon, B. J. Hong, H. Y. Park, W. Knoll, and J. W. Park, “DNA-DNA interaction on dendron-functionalized sol-gel silica films followed with surface Plasmon fluorescence spectroscopy” J. Colloid Interface Sci. 308, 325-331 (2007).

V. Sunkara, B. J. Hong, and J. W. Park, “Sensitivity enhancement of DNA microarray on nano-scale controlled surface by using a strepavidin-fluorophore conjugate”, Biosens. Bioelectron. 22, 1532-1537 (2007).

S. J. Oh, B. J. Hong, K. Y. Choi, and J. W. Park, “Surface Modification for DNA and Protein Microarrays”, OMICS: A Journal of Integrative Biology 10(3), 327-343 (2006).

B. J. Hong, S. J. Oh, T. O. Youn, S. H. Kwon, and J. W. Park, “Nanoscale-Controlled Spacing Provides DNA-microarrays with the SNP Discrimination Efficiency in Solution Phase”, Langmuir21, 4257-4261 (2005).

B. J. Hong, V. Sunkara, and J. W. Park, “DNA Microarrays on Nanoscale-Controlled Surface with a Dendron”, Nucleic Acids Res. 33(12), e106 (2005).

H. R. Byun, B. J. Hong, Y. S. Gho, J. W. Park, and H. C. Choi, “Pseudo 3D Single-Walled Carbon Nanotube Film for BSA-free Protein Chips”, ChemBioChem6, 1331-1334 (2005).

S. J. Oh, J. Ju, B. C. Kim, E. Ko, B. J. Hong, J. Park, J. W. Park, and K. Y. Choi, “DNA Microarrays on a Dendron-Modified Surface Improve Significantly the Detection of Single Nucleotide Variations in the p53 Gene”, Nucleic Acids Res. 33(10), e90 (2005).

B. J. Hong, J. Y. Shim, S. J. Oh, and J. W. Park, “Self-Assembly of a Dendron through Multiple Ionic Interaction to Give Mesospacing between Reactive Amine Groups on the Surface”, Langmuir 19, 2357-2365 (2003).

J. H. Moon, Y.–H. La, J. Y. Shim, B. J. Hong, K. J. Kim, T.-H. Kang, B. Kim, H. Kang, and J. W. Park, “Selective Cleavage of Carbon-Halide Bond in the Substituted Benzaldimine Monolayers by Synchrotron Soft X-ray: Anomalously Large Rate of the Carbon-Bromide Bond Cleavage”, Langmuir, 16, 2981-2984 (2000).

S. K. Chung, Y. U. Kwon, Y. T. Chang, K. H. Sohn, J. H. Shin, K. H. Park, B. J. Hong, and I. H. Chung, “Synthesis of All Possible Regioisomers of scyllo-Inositol Phosphate”, Bioorg. Med. Chem. 7, 2577-2589 (1999).